OPV Buffer Study

This study tries to determine whether administration of bicarbonate buffer increases the proportion of Bangladeshi infants developing serologic responses to types 1, 2, and 3 polioviruses after receipt of OPV and to assess the  impact of nutritional status on the vaccine response to OPV in Bangladesh infants.


An individually randomized controlled trial with 2 equal groups were conducted to test the effects of bicarbonate buffer on OPV immunogenicity. The intervention group has received buffer solution containing 64 mg of sodium bicarbonate plus 24 mg of sodium citrate in 2.5 ml of water. The buffer was administered prior to each dose of OPV. Infants received the same intervention at all three visits. The control group was not receive any intervention. All study participants received the oral polio vaccines along with routine EPI immunizations.


Healthy infants 6 weeks (±2 week) of age residing in the study area were recruited for the study. Community Health Workers (CHWs), through regular house visits, has identified healthy newborns of appropriate age. All eligible children were brought to study clinic at Zakigonj and Kanaighai Upazila Health Complex for enrollment, vaccination and blood collection. The vaccines were administered as per routine EPI program in Bangladesh which include BCG (Bacille Calmette-Guérin) at 0-6 weeks of age, pentavalent (DPT, HepB, Hib) vaccine and oral polio vaccine at 6, 10 and 14 weeks of age.

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